NLS Pharmaceutics Ltd. is a Swiss-based clinical-stage pharmaceutical company led by an experienced
management team with a track record of developing and repurposing product candidates to treat rare
and complex central nervous system disorders. The Company’s lead product candidate, Quilience® is a
proprietary controlled release formulation of mazindol (mazindol CR), and is being developed for the
treatment of narcolepsy. Mazindol is a triple monoamine reuptake inhibitor and partial orexin receptor 2
agonist, which was used for many yearsto treat patients diagnosed with narcolepsy in compassionate use
programs. NLS completed a phase 2 study in the U.S. evaluating mazindol CR in adult subjects with ADHD.
The study met all primary and secondary endpoints and was well-tolerated. Quilience® has received
Orphan Drug Designations both in the U.S. and in Europe for the treatment of narcolepsy.